lipoproteins receptors การใช้

• Tva contains sequences related to the ligand binding region of low-density lipoprotein receptors ( LDLR ).
• As members of lipoprotein receptor superfamily, both VLDLR and ApoER2 have in their structure an internalization domain called NPxY motif.
• Portions of the cytosolic sequence have been found in other lipoprotein receptors, as well as in more distant receptor relatives.
• LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor ( LDLR ).
• Splice variant d has a 100 % structural match to Low density lipoprotein receptor-related protein 4 ( LRP4 ).
• A beta-propeller is a critical component of LDLR ( low density lipoprotein receptor ) and aids in a pH based conformational change.
• A mechanism for liposome transport across the BBB is low-density lipoprotein receptor ( LDLR ) in the BBB and allows transport to occur.
• The intracellular adaptor DAB1 binds to the VLDLR and ApoER2 through an NPxY motif and is involved in transmission of Reelin signals through these lipoprotein receptors.
• They also found a link between cholesterol-related conditions, such as heart disease and stroke, and a lack of low-density lipoprotein receptors.
• While a postdoctoral fellow, S黡hof cloned the gene for the low-density lipoprotein receptor and, soon after, was able to explain its transcriptional regulation by cholesterol.
• It interacts with the Alzheimer's disease amyloid precursor protein ( APP ), transcription factor CP2 / LSF / LBP1 and the low-density lipoprotein receptor-related protein.
• In the central nervous system, APOE is mainly produced by astrocytes, and transports cholesterol to neurons via APOE receptors, which are members of the low density lipoprotein receptor gene family.
• Tumors overexpressing the Wnt signaling pathway co-receptor low-density lipoprotein receptor-related protein 6 ( LRP6 ) may represent a distinct subtype of breast cancer and a potential treatment target.
• This condition is caused by a mutation in apolipoprotein E ( ApoE ), that serves as a ligand for the liver receptors for chylomicrons, IDL and VLDL or Very Low Density lipoprotein receptors.
• The "'low-density lipoprotein receptor gene family "'codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types.
• These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.
• This splitting does not decrease the protein's activity, as constructs made of the predicted central fragments ( repeats 3 6 ) bind to lipoprotein receptors, trigger Dab1 phosphorylation and mimic functions of reelin during cortical plate development.
• -LRP8 : This gene encodes a member of the low density lipoprotein receptor ( LDLR ) family, a cell surface protein that plays a role in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation.
• The presence of low-density lipoprotein receptor type A ( LDLrA ) domains repeated ten times in the consensus sequence could provide a hint as to the function of SCORs, since LDLrA are known to interact with proteases or protease inhibitors.
• By targeted disruption experiments in mice, Trommsdorff et al . ( 1999 ) showed that 2 cell surface receptors, very low density lipoprotein receptor ( VLDLR; 192977 ) and apolipoprotein E receptor-2 ( ApoER2; 602600 ), are also required.